POST-DOC IN SYNAPTOGENESIS RESEARCH GROUP

Location Wrocław
Deadline 22.10.2021

We currently seek applicants for

POST-DOC  IN SYNAPTOGENESIS RESEARCH GROUP

Location: Wrocław, Poland

Ref. no. PhD/TP/2020

Synaptogenesis group is a laboratory conducting multidisciplinary research on skeletal muscles, neuromuscular junctions, and the brain. Our laboratory is multicultural with half of the lab members coming from abroad. We are committed to conduct innovative research on the best international level. Our resent publication Rojek K. et al., „Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice” published in Plos Biology 2019 May 1;17(5):e3000253 has been awarded with prestigious Konorski Award for the best publication in neuroscience in Poland published in 2019.

Currently, we are recruiting a post-doc to a project financed by National Science Center (NCN) grant 2020/37/B/NZ3/03909 “New mechanisms regulating acetylcholine receptors at the neuromuscular junction”. In this project we will study the molecular mechanisms that regulate stability and intracellular trafficking of postsynaptic receptors for neurotransmitter acetylcholine (AChR). AChRs have to be maintained at high density at the postsynaptic machinery in order to facilitate proper functioning of synapses. Many neuromuscular disorders are characterized by disruption of synapse integrity and removal of AChRs from the junctions. Surprisingly, little is known how AChR are endocytosed and transported inside of cells. We will search for novel proteins that bind to AChR and regulate its stability and transport. In this project we will use wide range of techniques including protein complex purification, mass spectrometry analysis, histology, live imaging of synapses and cells, genetic manipulations including conditional knockout mice and viral gene delivery. By joining the project, you will learn a lot of techniques from various fields of biology and the obtained results will likely be published in good international journals.

Major responsibilities

  • Planning, designing and conducting scientific experiments.
  • Writing manuscripts, presenting results at international scientific meetings.
  • Active participation in the laboratory operations.
  • Supervising Ph.D. students and technicians.

Expectations:

  • Ph.D. degree (or equivalents).
  • Scientific productivity proven in publication record.
  • Experience in laboratory work in the field of biology especially in cell biology, biochemistry, or neuroscience.
  • Leadership and excellent organizational skills.
  • Ability to work in a team.
  • Very good English (both written and spoken).
  • Experience in neuroscience, muscle research, and in mouse studies will be additional benefit.
  • Knowledge of any of the following techniques will be considered as added value: immunostaining of cells and tissues, confocal microscopy, Western-blot, co-immunoprecipitation, protein purification, molecular cloning, PCR and qRT-PCR, viral-based gene delivery, cell culture, performing experiments on mice, breading of transgenic and knockout animals.

Our offer:

  • Full time contract of employment for the position of a Senior Specialist.
  • Competitive salaries.
  • Work in young, dynamic and ambitious group.
  • Cutting edge research with a good publishing record of the group.
  • Training in the use of modern techniques including work with conditional knockout mice for tissue-specific deletion, complex biochemistry and protein complex purification, in vivo imaging of synapses.
  • We subsidies private medical care.

Please send your resume via link:

https://system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=f2d2ee87889c4a919ce58c2f56be8cb8

Application deadline: 22.10.2021

Please note that we will contact only selected candidates.